Bridging the gap between organic and polymer chemistries

The Laboratory of Organic and Polymer Chemistry





1. Barba, B.J.D.; Causapin, C.G.V.; Cabalar, P.J.E.; Luna, J.A.A.; Seko, N.; Omichi, M.; Kakuchi, R.; Madrid, J.F.*, "Pineapple Fiber Hybrids Prepared by the Fusion of radiation-induced Graft Polymerization and Kabachnik-Fields three-component Reaction (RIGP-KF3CR)". in press.

2. Kakuchi, R.*; Matsubara, K.; Madrid, J.F.; Barba, B.J.D.; Omichi, M.; Ueki, Y.; Seko, N.*, "A-la-carte surface functionalization of organic materials via the combination of radiation-induced graft polymerization and multi-component reactions". in press.

3. Matsubara, K.; Chou, L.C.; Amii, H.; Kakuchi, R.*, "Fast-Track Computational Access to Reaction Mechanisms Provides Comprehensive Insights into Aminolysis Postpolymerization Modification Reactions". Molecular Systems Design & Engineering, 2022, 7, 1263 - 1276.


1. Kakuchi, R.*; Fukasawa, K.; Chou, L.C.; Kim, H.; Amii, H.*, "Fundamental insights into aminolysis postpolymerization modification reaction of polymers featuring α,α-difluoroacetates esters". Polymer, 2021, 230(16), 124058.

2. Kakuchi, R.*; Matsubara, K.; Fukasawa, K.; Amii, H.*, "Unveiling α-Etherification Effects on the Aminolysis of α,α-Difluoroacetate Enables the Aminolysis Post-polymerization Modification of α,α-Difluoro-α-(aryloxy)acetate-Containing Polymers". Macromolecules, 2021, 54(13), 6204-6213.

3. Hirama, A.; Chou, L.C.; Kakuchi, R.*, "Streamlined access to end-functionalized thermoresponsive polymers via a combination of bulk RAFT polymerization and quasi solvent-free Passerini three-component reaction".Polym. J., 2021,53(11), 1175-1185.

  • Rising Stars in Polymer Science 2021の特集号に掲載されました。 in press.

4. Kakuchi, R.*; Tsuji, R.; Fukasawa, K.; Yamashita, S.; Omichi, M.; Seko, N.*, "Polymers of Lignin-Sourced Components as a Facile Chemical Integrant for the Passerini Three-Component Reaction". Polym. J., 2021,53(4), 523-531.

5. Takahashi, R.; Kakuchi, R.*, "Rational Optimization of the Petasis Three-Component Reaction as a Feasible Elementary Reaction in Polymer Chemistry". Macromol. Chem. Phys.,2021,222(2), 2000347.

6. Kakuchi, R.*; Fukasawa, K.; Kikuchi, M.; Narumi, A.; Kawaguchi, S.; Li, Y.; Kim, H.*; Amii, H.*, "Computer-Aided Design of Postpolymerization Modification Reaction Based on Aminolysis of α,α-Difluoroacetate Esters". Macromolecules, 2021, 54(1), 364-372.

  • Supplementary Journal Coverとして採択されました。


1. Kakuchi, R.* and Okura, Y., "The Passerini three-component reaction of aldehyde end-functionalized polymers via RAFT polymerization using chain transfer agents featuring aldehyde." Polym. J., 52 (9), 1057-1066.


1. Omichi, M.*; Yamashita, S.; Okura, Y.; Ikutomo, R.; Ueki, Y.; Seko, N.; Kakuchi, R.*, "Surface Engineering of Fluoropolymer Films via the Attachment of Crown Ether Derivatives Based on the Combination of Radiation-Induced Graft Polymerization and the Kabachnik–Fields Reaction." Polymers, 2019, 11 (8), 1337. (Open access paper)

  • Journal Coverとして採択されました。

2. Kakuchi, R.*, "The dawn of polymer chemistry based on multicomponent reactions" Polym. J. 2019, 51, 945-953. ここからどなたでも閲覧可能です

3. Hamada, T.*; Yamashita, S.; Omichi, M.; Yoshimura, K.; Ueki, Y.; Seko, N.; Kakuchi, R.*, "Multicomponent-Reaction-Ready Biomass-Sourced Organic Hybrids Fabricated via the Surface Immobilization of Polymers with Lignin-Based Compounds" ACS Sustainable Chem. Eng. 2019, 7 (8), 7795-7803.

  • Supplementary Journal Coverとして採択されました。
  • 大学・QSTよりプレスリリース。
  • 6/10付で化学工業日報に掲載
  • 6/13付で群馬経済新聞に掲載
  • 7/1付で上毛新聞に掲載
  • 7/2付で上毛新聞の記事がYahoo!Newsに掲載

4. Hirose, D.; Wardhana Kusuma, S. B.; Nomura, S.; Yamaguchi, M.; Yasaka, Y.; Kakuchi, R.; Takahashi, K., "Effect of anion in carboxylate-based ionic liquids on catalytic activity of transesterification with vinyl esters and the solubility of cellulose." RSC Adv. 2019, 9 (7), 4048-4053.


    1. Kakuchi, R.*; Yoshida, S.; Sasaki, T.; Kanoh, S.; Maeda, K.*,"Multi-Component Post-Polymerization Modification Reactions of Polymers Featuring Lignin-Model Compounds." Polym. Chem. 2018, 9 (16), 2109-2115.

    2. Yan, F.; Kakuchi, R.; Takahashi, K.; Kim, H. J.*, "CS2 capture in the ionic liquid 1-alkyl-3-methylimidazolium acetate: reaction mechanism and free energetics." Phys. Chem. Chem. Phys. 2018, 20 (29), 19339-19349.

    3. Suzuki, S.; Shibata, Y.; Hirose, D.; Endo, T.; Ninomiya, K.; Kakuchi, R.*; Takahashi, K.*, "Cellulose triacetate synthesis via one-pot organocatalytic transesterification and delignification of pretreated bagasse." RSC Adv. 2018, 8 (39), 21768-21776.

    4. Sakai, H.; Kuroda, K.; Muroyama, S.; Tsukegi, T.; Kakuchi, R.; Takada, K.; Hata, A.; Kojima, R.; Ogoshi, T.; Omichi, M.; Ninomiya, K.; Takahashi, K., "Alkylated alkali lignin for compatibilizing agents of carbon fiber-reinforced plastics with polypropylene" Polym. J. 2018, 50 (3), 281-284.


    1. Quy, N. V.; Nomura, S.; Hoshino, R.; Ninomiya, K.; Takada, K.*; Kakuchi, R.*; Takahashi, K.*,"Recyclable and Scalable Organocatalytic Transesterification of Polysaccharides in a Mixed Solvent of 1-Ethyl-3-methylimidazorium Acetate and Dimethyl Sulfoxide." Polym. J. 2017, 49 (11), 783-787.

    2. Kakuchi, R.; Ito, R.; Nomura, S.; Abroshan, H.; Ninomiya, K.; Ikai, T.; Maeda, K.; Kim, H. J.; Takahashi, K., "A mechanistic insight into the organocatalytic properties of imidazolium-based ionic liquids and a positive co-solvent effect on cellulose modification reactions in an ionic liquid." (a aprt of the collection, Ionic Liquids: Editors collection for RSC Advances) RSC Adv. 2017, 7 (16), 9423-9430.


1. Moldenhauer, F.; Kakuchi, R.; Theato, P., "Synthesis of Polymers via Kabachnik-Fields Polycondensation." ACS Macro Lett. 2016, 5 (1), 10-13.
(highlighted in Synfacts by Prof. Swager at MIT, Swager, T. M.; Fennell, J. F., "Good Things Come in Threes: Kabachnik-Fields Polycondensation." Synfacts 2016, 12 (03), 0255.)


    1. Ninomiya, K.; Omote, S.; Ogino, C.; Kuroda, K.; Noguchi, M.; Endo, T.; Kakuchi, R.; Shimizu, N.; Takahashi, K., "Saccharification and ethanol fermentation from cholinium ionic liquid-pretreated bagasse with a different number of post-pretreatment washings." Bioresour. Technol. 2015, 189, 203-9.

    2. Ninomiya, K.; Kohori, A.; Tatsumi, M.; Osawa, K.; Endo, T.; Kakuchi, R.; Ogino, C.; Shimizu, N.; Takahashi, K., "Ionic liquid/ultrasound pretreatment and in situ enzymatic saccharification of bagasse using biocompatible cholinium ionic liquid." Bioresour. Technol. 2015, 176 (0), 169-174.

    3. Kakuchi, R.; Yamaguchi, M.; Endo, T.; Shibata, Y.; Ninomiya, K.; Ikai, T.; Maeda, K.; Takahashi, K., "Efficient and rapid direct transesterification reactions of cellulose with isopropenyl acetate in ionic liquids." RSC Adv. 2015, 5 (88), 72071-72074.

    4. Kakuchi, R., "Recent Developments in Polymer Analogous Reactions." Kobunshi Ronbunshu 2015, 72 (9), 550-560.


    1. Kakuchi, R.; Wongsanoh, K.; Hoven, V. P.; Theato, P., "Activation of stable polymeric esters by using organo-activated acyl transfer reactions." J. Polym. Sci. Part A 2014, 52 (9), 1353-1358.

    2. Kakuchi, R.; Theato, P., Efficient Multicomponent Postpolymerization Modification Based on Kabachnik-Fields Reaction. ACS Macro Lett. 2014, 3 (4), 329-332.
    (highlighted in Synfacts by Prof. Swager at MIT, Swager, T. M.; Sterner, E. S., Poly(α-aminophosphonates) by MCR without Isocyanides. Synfacts 2014, 10 (06), 0592.)

    3. Kakuchi, R.; Yamaguchi, M.; Endo, T.; Shibata, Y.; Ninomiya, K.; Ikai, T.; Maeda, K.; Takahashi, K., "Efficient and rapid direct transesterification reactions of cellulose with isopropenyl acetate in ionic liquids." RSC Adv. 2015, 5 (88), 72071-72074.

    4. Kakuchi, R.; Theato, P., "Preparation of Functional Polyamine Scaffolds via Mitsunobu Post-Polymerization Modification Reactions." Macromol. Rapid Commun. 2014, 35 (6), 661-665.

    5. Kakuchi, R.; Theato, P., "Sequential post-polymerization modification reactions of poly(pentafluorophenyl 4-vinylbenzenesulfonate)." Polym. Chem. 2014, 5 (7), 2320-2325.

    6. Kakuchi, R.*, "Multicomponent reactions in polymer synthesis." Angew. Chem. Int. Ed. 2014, 53 (1), 46-48.


    1. Zhao, H.; Gu, W.; Kakuchi, R.; Sun, Z.; Sterner, E.; Russell, T. P.; Coughlin, E. B.; Theato, P., "Photocleavable Triblock Copolymers Featuring an Activated Ester Middle Block: “One-Step” Synthesis and Application as Locally Reactive Nanoporous Thin Films." ACS Macro Lett. 2013, 2 (11), 966-969.

    2. Kakuchi, R.; Theato, P., Three-Component Reactions for Post-Polymerization Modifications. ACS Macro Lett. 2013, 2 (5), 419-422.


    1. Kakuchi, R.; Zamfir, M.; Lutz, J.-F.; Theato, P., Controlled Positioning of Activated Ester Moieties on Well-Defined Linear Polymer Chains. Macromol. Rapid Commun. 2012, 33 (1), 54-60.

    2. Kakuchi, R.; Theato, P., Changing the Reactivity of Polymeric Activated Esters by Temperature: On-Off Switching of the Reactivity of Poly(4-acryloxyphenyldimethylsulfonium triflate). Macromolecules 2012, 45 (3), 1331-1338.


    1. Kakuchi, R., Metal-Catalyzed Multicomponent Reactions for the Synthesis of Polymers. In Advances in Polymer Science, Springer Berlin Heidelberg: 2015; pp 1-15.

    2. Kakuchi, R.; Theato, P., Post-Polymerization Modifications via Active Esters. In Functional Polymers by Post-Polymerization Modification, Wiley-VCH Verlag GmbH & Co. KGaA: 2012; pp 45-64.